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Grand News Network | November 6, 2023

TILT Biotherapeutics Announces Positive Clinical Data on Lead Asset TILT-123 at Society for Immunotherapy of Cancer 2023

HELSINKI, Finland, Nov. 06, 2023 (GLOBE NEWSWIRE) -- TILT Biotherapeutics (TILT), a clinical-stage biotechnology company at the forefront of developing cancer immunotherapies, presented Phase I data on its TILT-123 monotherapy, a T-cell activating oncolytic virus for advanced solid tumor patients, in a late-breaking poster at the Society for Immunotherapy of Cancer 2023 conference (SITC - San Diego, 1-5 November).

Poster (1) demonstrates the remarkable safety profile of TILT-123 monotherapy and showcases promising efficacy results, including anti-tumor activity and the induction of immune responses across different cancer types in patients who had exhausted traditional treatment options. TILT-123 was shown to achieve anti-tumor responses as a monotherapy, which can be seen in injected and non-injected lesions. See here for all four posters.

Notably, TILT-123 monotherapy exhibited excellent tolerability, consistent with other oncolytic virus therapies, opening the door to potential combination therapies. Several such trials are currently underway, reflecting TILT's commitment to pushing the boundaries of cancer treatment (NCT04217473, NCT05271318, NCT05222932).

TILT Biotherapeutics' founder and CEO, Akseli Hemminki, a cancer clinician who has personally treated hundreds of cancer patients with oncolytic viruses, said:

"These results from our TUNIMO trial are extremely promising. Our approach shows the potential to make a significant impact in the fight against advanced solid tumors. We are dedicated to advancing the field of cancer immunotherapy and will continue to explore combination therapies and innovative treatment strategies. We thank the patients, and all our academic, clinical, and industry collaborators for their critical contributions to the studies."

TILT-123 is an oncolytic adenovirus encoding for interleukin-2 and tumor necrosis factor alpha, designed for recruiting, propagating, and stimulating T-cells ...

Full story available on Benzinga.com


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